Part:BBa_K5499003
Exosignal
Exosignal is a signaling peptide characterized by the KFERQ motif.With Exosignal, targeted protein can be more easily loaded into exosomes.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
profile
Name: Exosignal
Base Pairs: 57 bp
Origins: Exosignal is a signaling peptide that has its origins in cellular processes related to autophagy and exosome-mediated communication.
Properties: The KFERQ motif allows Exosignal to facilitate the selective recognition and targeting of cytosolic proteins, marking them for incorporation into exosomes.
Usage and Biology
The biological function of Exosignal revolves around its role in the efficient incorporation of targeted proteins into exosomes, crucial for cellular communication and waste management. Exosomes are vital in various physiological processes, including immune response regulation, tissue repair, and cellular homeostasis. By guiding proteins with the KFERQ motif into exosomes, Exosignal ensures that specific proteins are transported to recipient cells, where they can influence cellular function and modulate biological pathways.
Exosignal is of particular interest in disease contexts such as cancer and neurodegenerative disorders. In cancer, exosomes containing proteins with oncogenic potential can promote tumor progression and metastasis by altering the behavior of neighboring or distant cells. In neurodegenerative diseases, Exosignal may facilitate the clearance of misfolded or damaged proteins through exosome-mediated pathways, potentially offering a mechanism to mitigate protein aggregation and cellular toxicity.
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