Part:BBa_K5487008

Sfp

The Sfp gene encodes surfactant protein A (SP-A) phosphopantetheinyl transferase.This enzyme is crucial for the post-translational modification of acyl carrier proteins (ACPs) and other similar proteins by attaching a phosphopantetheine group derived from coenzyme A (CoA).This modification is essential for the functionality of ACPs in various biosynthetic pathways, including fatty acid synthesis, polyketide production, and non-ribosomal peptide synthesis. The primary function of Sfp is to catalyze the attachment of the 4'-phosphopantetheine prosthetic group to the serine residue of ACPs. This modification activates the ACPs, allowing them to participate in the synthesis of complex molecules by acting as carriers for malonyl or other extender units. The 4'-phosphopantetheine arm facilitates the transfer of these units during the assembly of the final product.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  INCOMPATIBLE WITH RFC[1000]

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