Coding
Part:BBa_K5477020:Design
Designed by: Kate Malana Escobar Group: iGEM24_UCopenhagen (2024-09-26)
CYP3A4 - Cytochrome P450 3A4 codon-optimized for Saccharomyces cerevisiae
Assembly Compatibility:
- 10INCOMPATIBLE WITH RFC[10]Illegal XbaI site found at 1483
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal XbaI site found at 1483
- 25INCOMPATIBLE WITH RFC[25]Illegal XbaI site found at 1483
- 1000COMPATIBLE WITH RFC[1000]
Design Notes
In the context of our system, CYP3A4 is integrated into a detoxification module where it initiates the oxidative breakdown of toxic compounds, such as pharmaceuticals and environmental pollutants, allowing these substances to be further processed and excreted. The inclusion of CYP3A4 in our detox module provides a broad-spectrum solution for metabolizing diverse toxins and drugs.
Source
Homo sapiens