Part:BBa_K5477020
CYP3A4 - Cytochrome P450 3A4 codon-optimized for Saccharomyces cerevisiae
CYP3A4 (Cytochrome P450 3A4) is one of the enzymes in the cytochrome P450 family responsible for the metabolism of a wide variety of xenobiotics, including drugs, environmental chemicals, and endogenous compounds (2) (4). CYP3A4 metabolizes approximately 50% of all clinically used drugs (1). CYP3A4 is predominantly found in the liver and the intestines, where it plays a role in phase I metabolism (2). CYP3A4 catalyzes the oxygenation of its substrates (2).
CYP3A4, as a part, was integrated into a detoxification module where it initiates the oxidative breakdown of toxic compounds, such as pharmaceuticals and environmental pollutants, allowing these substances to be further processed and excreted (4). This part was combined with POR forming this composite BBa_K5477038.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal XbaI site found at 1483
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal XbaI site found at 1483
- 25INCOMPATIBLE WITH RFC[25]Illegal XbaI site found at 1483
- 1000COMPATIBLE WITH RFC[1000]
References
1. Bardal SK, Waechter JE, Martin DS. Chapter 6 - Pharmacogenetics. In: Bardal SK, Waechter JE, Martin DS, editors. Applied Pharmacology [Internet]. Philadelphia: W.B. Saunders; 2011. p. 53–8. Available from: https://www.sciencedirect.com/science/article/pii/B9781437703108000063
2. Guengerich, F.. (2008). Cytochrome P450 and Chemical Toxicology. Chemical research in toxicology. 21. 70-83. 10.1021/tx700079z.
3. Klyushova LS, Perepechaeva ML, Grishanova AY. The Role of CYP3A in Health and Disease. Biomedicines. 2022 Oct 24;10(11):2686. doi: 10.3390/biomedicines10112686. PMID: 36359206; PMCID: PMC9687714.
4. Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007;76(3):391-396.
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