Part:BBa_K5310008
CD8a Transmembrane
The CD8a transmembrane (TMD) domain is an important structural component mediating external ligand binding and intracellular signaling. This domain anchors the receptor in the cell membrane. Although weaker than the CD28 alternative, it has been known to make CAR-T cells safer and more durable. We added it to our chimeric autoantibody receptor part collection, to add an option that can increase the durability of the Tregs we propose to create in our future implementation. CAR T cells with CD8α hinge (BBa_K5310007 of our collection) and CD8a transmembrane domains have been shown to release less IFNγ and TNF and are less susceptible to activation-induced cell death than those in which these domains are derived from CD28.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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