Part:BBa_K5310003
Myelin Basic Protein domain (aa 83-99)
The amino acid sequence 83-99 of myelin basic protein (MBP) is a particular peptide segment derived from MBP, a key structural protein of the myelin sheath in the central nervous system (CNS). The sequence itself has been identified as a prominent epitope in autoimmune responses, particularly multiple sclerosis (MS). This region can activate the immune system by activating T-cells, which recognize it as a component of the CNS myelin. In MS, the immune response degrades the myelin sheath, resulting in decreased nerve signaling and gradual neurological impairment. The MBP 83-99 peptide is thus important in the study of autoimmune illnesses such as MS, and it is frequently utilized in immunological research to evaluate demyelination mechanisms and prospective therapeutic approaches.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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