Coding

Part:BBa_K5238004:Design

Designed by: Yishi Jia   Group: iGEM24_NJMU-CHINA   (2024-07-10)


Produce niacin for the treatment of depression


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

https://www.ncbi.nlm.nih.gov/gene/15552358


Source

References: 1. Chen, M., Wang, X., Wang, Y., Zhao, G., & Zhang, D. (2023). Activation of the HCAR2 Receptor by Niacin Modulates Microglial Response to Amyloid Plaques in Alzheimer's Disease Models. Journal of Neuroinflammation, 21(1), 45-58. 2. Gao, H., Liu, Q., & Yan, Y. (2014). Antidepressant-Induced Reduction of Interferon-γ and Its Implications for Kynurenine Pathway in Major Depressive Disorder. Medical Hypotheses, 83(3), 210-215. 3. Li, L., Zhang, Z., & Dong, J. (2023). Niacin Reverses PHA-Induced Damage in F-98 Cells by Modulating Neuroinflammation Markers and TREM-2/DAP-12 Pathway. Brain Research, 1821(4), 217-229.

References