Part:BBa_K5191004

Spermidine Synthase

Spermidine synthase is a key enzyme involved in polyamine biosynthesis, specifically converting putrescine into spermidine. This enzyme catalyzes the reaction between putrescine and decarboxylated S-adenosylmethionine (dcSAM), resulting in the formation of spermidine and methylthioadenosine. Spermidine plays a crucial role in cell growth and proliferation by influencing cell cycle regulation, gene expression, and responses to oxidative stress and nutrient deprivation. Additionally, it is associated with autophagy processes, potentially affecting cellular aging and lifespan, and it exhibits neuroprotective effects on neural cells. These functions highlight the significant role of spermidine synthase in cellular physiology and medical research.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]