RNA
miR-484

Part:BBa_K5106000

Designed by: Ivar Gruppen   Group: iGEM24_WageningenUR   (2024-09-26)


microRNA shown to be upregulated in multiple sclerosis

This miRNA is present in the blood, and has been shown to be present at significantly higher levels in people with relapsing-remitting multiple sclerosis, compared to healthy people.1 Because of this, this miRNA can be used as the target for detection in the development of new diagnostic methods for MS.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

  1. Regev, K.; Healy, B. C.; Paul, A.; Diaz-Cruz, C.; Mazzola, M. A.; Raheja,

R.; Glanz, B. I.; Kivis¨akk, P.; Chitnis, T.; Jagodic, M.; Piehl, F.; Ols- son, T.; Khademi, M.; Hauser, S.; Oksenberg, J.; Khoury, S. J.; Weiner, H. L.; Gandhi, R. Identification of MS-specific serum miRNAs in an inter- national multicenter study. Neurology Neuroimmunology & Neuroinflam- mation 2018, 5, Publisher: Wolters Kluwer, e491.


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