Protein_Domain

Part:BBa_K4803005

Designed by: Kotaro MURAI   Group: iGEM23_UTokyo   (2023-10-10)


CD4 signal

This part is a CD4-derived signal peptide. When this part is translated, it is recognized by the signal recognition particle and the protein undergoing synthesis is transferred to the endoplasmic reticulum.

This part is adapted from the signal peptide of a protein used in the MESA system described in [1].

In UTokyo2023 project, this part is commonly used as a signal peptide for the proteins that make up the MESA (Modular Extracellular Sensor Architecture) system [1].

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Reference

[1] Daringer, N. M., Dudek, R. M., Schwarz, K. A., & Leonard, J. N. (2014). Modular extracellular sensor architecture for engineering mammalian cell-based devices. ACS synthetic biology, 3(12), 892-902. https://doi.org/10.1021/sb400128g



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