RNA

Part:BBa_K4789001:Design

Designed by: Fangyuan Duan   Group: iGEM23_YiYe-China   (2023-09-17)


miR-145-sponge


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

miR-145-sponge was designed according to the binding site between miR-22 and lncRNA MALAT1.

Source

The miR-145-sponge were synthesized by Nanjing Genscript Biotechnology corporation.

References

1.Han Xiting,Wang Qian,Wang Yan et al. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1/microRNA-202-3p/periostin axis modulates invasion and epithelial-mesenchymal transition in human cervical cancer.[J] .J Cell Physiol, 2019, 234: 14170-14180.

2.Shen Fujin,Zheng Hongyun,Zhou Limei et al. Overexpression of MALAT1 contributes to cervical cancer progression by acting as a sponge of miR-429.[J] .J Cell Physiol, 2019, 234: 11219-11226.

3.Aftab Mehreen,Poojary Satish S,Seshan Vaishnavi et al. Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer.[J] .Sci Rep, 2021, 11: 10323.

4.Chen Mingming,Ma Zhao,Wu Xiaotian et al. A molecular beacon-based approach for live-cell imaging of RNA transcripts with minimal target engineering at the single-molecule level.[J] .Sci Rep, 2017, 7: 1550.

5.Hu Chenchen,Liu Tianyue,Zhang Wenxin et al. miR-145 inhibits aerobic glycolysis and cell proliferation of cervical cancer by acting on MYC.[J] .FASEB J, 2023, 37: e22839.