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Part:BBa_K4600001

Designed by: Kavirang Biswas   Group: iGEM23_Warwick   (2023-09-21)


AcrB is a part of a multidrug efflux pump system found commonly in E.coli.

AcrB along with AcrA and TolC form a tripartite multidrug efflux pump system that can recognise and extricate multiple antibiotics, and other compounds. AcrB is the inner membrane compound that is mainly responsible for substrate recognition. AcrB is also a part of the Resistance Nodulation cell Division (RND) family, and therefore is most common in gram negative bacteria.

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal EcoRI site found at 2830
    Illegal PstI site found at 937
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal EcoRI site found at 2830
    Illegal PstI site found at 937
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal EcoRI site found at 2830
    Illegal XhoI site found at 773
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal EcoRI site found at 2830
    Illegal PstI site found at 937
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal EcoRI site found at 2830
    Illegal PstI site found at 937
    Illegal NgoMIV site found at 859
    Illegal NgoMIV site found at 1831
    Illegal NgoMIV site found at 1864
  • 1000
    COMPATIBLE WITH RFC[1000]


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Parameters
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