Part:BBa_K4574019
IGHG1
Human immunoglobulin heavy chain constant gamma (Cγ) region derived from the IGHG1 gene. This sequence represents the constant domain of the gamma heavy chain, integral to the structure and function of antibodies.
Source
The following basic part has a genomic origin[1].
| Organism | Homo sapiens (human) |
| Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Gene | IGHG1: immunoglobulin heavy constant gamma 1 (NCBI 3500) |
| Location | 14q32.33, 105743071←105741473 |
It was first identified and sequenced by Takahashi et al.[2].
The provided sequence was derived through back-translation from the resulting peptide. This back-translation took into account the codon usage bias for expression in mammalian cells (see "Usage and Biology" section). Additionally, the sequence was designed to comply with the BioBrick assembly standards.
Usage and Biology
This basic part has been used as a component of several antibody constructs in mammalian cell culture (HEK293T, Exi293, RAMOS).
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
References
- ↑ Gene [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004 – [cited 2023 Oct 01]. Available from: https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=3500
- ↑ Takahashi, N., Ueda, S., Obata, M., Nikaido, T., Nakai, S., & Honjo, T. (1982). Structure of human immunoglobulin gamma genes: Implications for evolution of a gene family. Cell, 29(2), 671–679. https://doi.org/10.1016/0092-8674(82)90183-0
| None |