Part:BBa_K4020011

Usage and Biology

SIDs (SRCR-interspersed domains) are roughly 20-amino-acid-long threonine-serine-proline-rich stretches consisting of a number of glycosylation sites that proposedly render the linkers to extended conformation, spanning 7 nm (Reichhardt et al., 2020; Turenchalk & Xu, 2001). They are intrinsically disordered regions separating the SRCR domains in the SALSA protein. It is synthetic DNA.

References

• Reichhardt, M. P., Loimaranta, V., Lea, S. M., & Johnson, S. (2020). Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold. Life Science Alliance, 3(4). https://doi.org/10.26508/LSA.201900502
• Turenchalk, G. S., & Xu, T. (2001). Lats in Cell-cycle Regulation and Tumorigenesis BT - Encyclopedic Reference of Cancer. Encyclopedic Reference of Cancer, 491–496. https://doi.org/10.1007/3-540-30683-8_944