Signalling

Part:BBa_K3959002

Designed by: Richard Hou   Group: iGEM21_THIS-China   (2021-10-01)


CSP-1 Competence Signalling Peptide-1 in S.mutans

CSP is a 17 amino acid long small-peptide pheromone ribosomal synthesized and secreted by Streptococcus mutans and Strptococcus pneumoniae, which is a quorum sensing molecule that is commonly found in human dental plaque.

T--THIS-China--CSP picture.png

CSP can be detected by other S. mutans bacteria and leads them to release toxins that kill surrounding bacteria in order to help other S. mutans bacteria form a biofilm on the teeth surface. It regulates gene expression by interacting with ComD and ComE.

T--THIS-China--CSP ComDE system picture.png

References

Anaspec. “CSP-1, Competence-Stimulating Peptide-1 - 1 Mg.” Anaspec, https://www.anaspec.com/en/catalog/csp-1-competence-stimulating-peptide-1-1-mg~4cf4ff4e-50b6-45a4-8e97-6479ff2b3d36#:~:text=Competence%20stimulating%20peptide-1%20is%20a%2017%20amino%20acids,The%20pheromone%20is%20ribosomally%20synthesized%20as%20precursor%20peptide.

Team:SZPT-China, https://2020.igem.org/Team:SZPT-CHINA.

UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. “Competence-Stimulating Peptide Type 1.” UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics, 2 June 2021, https://www.uniprot.org/uniprot/P60242.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None