Part:BBa_K3959002

CSP-1 Competence Signalling Peptide-1 in S.mutans

CSP is a 17 amino acid long small-peptide pheromone ribosomal synthesized and secreted by Streptococcus mutans and Strptococcus pneumoniae, which is a quorum sensing molecule that is commonly found in human dental plaque.

CSP can be detected by other S. mutans bacteria and leads them to release toxins that kill surrounding bacteria in order to help other S. mutans bacteria form a biofilm on the teeth surface. It regulates gene expression by interacting with ComD and ComE.

References

Anaspec. “CSP-1, Competence-Stimulating Peptide-1 - 1 Mg.” Anaspec, https://www.anaspec.com/en/catalog/csp-1-competence-stimulating-peptide-1-1-mg~4cf4ff4e-50b6-45a4-8e97-6479ff2b3d36#:~:text=Competence%20stimulating%20peptide-1%20is%20a%2017%20amino%20acids,The%20pheromone%20is%20ribosomally%20synthesized%20as%20precursor%20peptide.

Team:SZPT-China, https://2020.igem.org/Team:SZPT-CHINA.

UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. “Competence-Stimulating Peptide Type 1.” UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics, 2 June 2021, https://www.uniprot.org/uniprot/P60242.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]