Part:BBa_K3955101
DB3DB3 peptide fused with slpmod signal peptide
DB3DB3 is a peptide designed for inhibition of amyloid beta aggregation [1]. It has also shown to have inhibitory effects on curli fibre elongation [2].
SLPmod is a signal peptide for secretion and an existing part in the registry: https://parts.igem.org/Part:BBa_K3183008 SLPmod has been shown to be effective in L. lactis [3].
References
1. Klein A, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A et al. Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination. PLOS ONE. 2016;11(4):e0153035.
2. Perov S, Lidor O, Salinas N, Golan N, Tayeb- Fligelman E, Deshmukh M et al. Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents. PLOS Pathogens. 2019;15(8):e1007978.
3. Fernandez A, Horn N, Wegmann U, Nicoletti C, Gasson M, Narbad A. Enhanced Secretion of Biologically Active Murine Interleukin-12 by Lactococcus lactis. Applied and Environmental Microbiology. 2009;75(3):869-871.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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