Coding

Part:BBa_K3846120

Designed by: Marcel Arvid Zimmeck   Group: iGEM21_Hamburg   (2021-10-15)


Hydroxymethylglutaryl-CoA synthase (HMGCS1) - MevT Pathway (phytobrick)

This phyto brick features the codon-optimised coding sequence of Hydroxymethylglutaryl-CoA synthase (HMGCS1) from Homo sapiens. This enzyme the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.

5' fusion site: TTCG

3' fusion site: GCTT

ttcg - gctt

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None