Coding

Part:BBa_K3582204

Designed by: Avadhoot Jadhav, Merrin Vincent   Group: iGEM20_IISER-Pune-India   (2020-10-22)


Inhibitory Peptide sequence 2 for PfEMP1-EPCR interaction

The following characteristic properties are observed in the inhibitory peptide sequence:

1] Interaction Energy:-7.2986 kcal/mol

2] Stability Value: 10.6872 dG units


This bio brick synthesizes the inhibitory peptide sequence that is believed to bind more efficiently as Compared to the wild type sequence. The peptide sequence is the particular hybrid sequence obtained using saturated mutagenesis. It shows comparatively more interactive properties and is assumed to show better binding strength.

Figure 1.Structure of the interacting domain of PfEMP1 Protein with inhibitory peptide sequence 1.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

1] https://www.rcsb.org/structure/4v3d



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