Coding

Part:BBa_K3346003:Design

Designed by: Emily Laskey   Group: iGEM20_Rochester   (2020-10-08)


Siltuximab Full Length IgG


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

This BioBrick was designed for efficient expression in E. coli SHuffle by performing codon optimization for an E. coli chassis using Reverse Translate Software available on The Sequence Manipulation Suite. The constant region is mutated for better Fc receptor binding.


Source

The sequences in this part were found on UniProt database and DrugBank database.

References