RNA

Part:BBa_K2534000:Design

Designed by: Mohammad Tarek Mansour   Group: iGEM18_AFCM-Egypt   (2018-09-24)


miRNA 370 5p miRNA-370 5p has been discovered to function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling. [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] worked to do lentiviral transfection of that part into colorectal cancer cell line RKO to induce regulatory apoptosis as well as to investigate it's immune modulatory effect on TLR-9. [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] have characterized this part considering it's apoptotic effect of RKO cell lines.

For further information about demonstration of its apoptotic effect, please visit our results page http://2018.igem.org/Team:AFCM-Egypt/Demonstrate For further information about design of our parts, please visit our Parts & Design Page http://2018.igem.org/Team:AFCM-Egypt/Parts

Ch370afcm.png

This part has been modeled structurally and prepared for docking studies. for more details please visit our modeling page http://2018.igem.org/Team:AFCM-Egypt/Model

T--AFCM-Egypt--3rd_pic.png


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

this part has been synthesized through IDT offer


Source

http://2018.igem.org/Team:AFCM-Egypt/Bioinformatics_Page_link