Part:BBa_K2520041

Peanut epitope 1 - Arah2 / Arah6

Peanut Allergy

Allergies to peanuts are a major public health concern and life threatening. 1-2% of the population suffers from this allergy. Common symptoms include acute allergic rash, acute vomiting, laryngeal oedema, hypotension, and dysrhythmia. The major allergy inducing proteins in peanuts are generally considered to be Ara h 1 and Ara h 3 that are members of the cupin superfamily of proteins.

Epitopes

The major peanut allergens are Ara h1, Ara h2, and Ara h3

Peanut 1 (Ara h1):

Ara h1 is a 35KD glycoprotein belongs to the vicilin (7S) family. Constitutes 12–16% of the total peanut protein and Affects 35–95% of peanut-allergic people. Native Ara h 1 exists as a trimer formed by three identical monomers.

Figure 1: IgE epitopes are mapped on the surface of the 3D model of Ara h 1 core region

References

(1) Al-Muhsen, Saleh, Ann E. Clarke, and Rhoda S. Kagan. "Peanut allergy: an overview." Canadian Medical Association Journal 168.10 (2003): 1279-1285.

(2) Mueller, Geoffrey A., Soheila J. Maleki, and Lars C. Pedersen. "The molecular basis of peanut allergy." Current allergy and asthma reports 14.5 (2014): 1-9.‏

(3) Zhou, Yang, et al. "Peanut allergy, allergen composition, and methods of reducing allergenicity: A review." International journal of food science 2013 (2013).‏

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]