Coding

Part:BBa_K2486113

Designed by: Tiago Lubiana Alves   Group: iGEM17_USP-Brazil   (2017-10-27)


Anti-malarial peptide (MP2)2 (no stop codon)

[theoretical part] [not assembled, not synthesized, not sent, not characterized]

Anti malarial peptide that binds to tP2 binds to a universal receptor for midgut invasion in Anopheles mosquitos. (1) Used in paratransgenic approaches to block Plasmoidum transmission. (2)

1- Vega-Rodríguez, Joel, et al. "Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut." Proceedings of the National Academy of Sciences 111.4 (2014): E492-E500.

2 - Wang, Sibao, et al. "Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria." Science 357.6358 (2017): 1399-1402.

Sequence codon optized to E. coli with https://www.idtdna.com/CodonOpt


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None