Part:BBa_K2307003
unc-60 - actin-binding proteins that regulate actin filament dynamics in C.elegans
Unc-60 encodes two, tissue-specific isoforms of actin depolymerizing factor(ADF)/cofilin. These proteins are actin-binding proteins that regulate actin filament dynamics. UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization. UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio. UNC-60B is required for actin filament organization in body wall muscle, and locomotion. UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca. unc-60 transcripts undergo muscle-specific pre-mRNA processing, regulated by the ASD-2 and SUP-12 splicing factors.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 335
Illegal XhoI site found at 1024 - 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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