Plasmid

Part:BBa_K1391108:Experience

Designed by: Shinjini Saha   Group: iGEM14_MIT   (2014-10-17)

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Applications of BBa_K1391108

Lyn is a Tyrosine-protein kinase responsible for phosphorylating the immunoreceptor tyrosine-based activation motif (ITAM) of a B-Cell Receptor (BCR) Complex upon antigen binding. When the BCR binds it's specific antigen the receptor dimerizes and recruits Lyn which phosphorylates the ITAMs of the CD79A and CD79B proteins in the BCR Complex. This allows the receptor to phosphorylate Syk and initiate a downstream signalling cascade. This part is under a constitutive hEF1a promoter for mammalian cells.


User Reviews

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