Part:BBa_K1228004

A fragment of loctoferrin

Lactoferrin (Lf) is a multifunctional member of the transferrin. Lf is found at the mucosal surface where it functions as a prominent component of the first line of the host defense system against infection and inflammation. This part is coding for 25 aminacid peptide that is a part of Lactoferrin. This peptide has a broad spectrum of anti-infection and anti-inflammatory function. Also, lactoferrin has a broad anti-bacterial range and strong anti-bacterial activity.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

MIT_MAHE 2020

Summary

Lactoferrin is a multifunctional protein from the transferrin group, which is assigned to serine proteases due to its enzymatic activity. In addition, lactoferrin also has nuclease activity and is an iron chelator. Lactoferrin consists of a polypeptide chain with about 700 amino acids and forms two similar globular domains called N-lobes and C-lobes, connected by a short alpha helix. Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity and is part of the innate defense. It reduces inflammation factors and thus promotes the absorption of iron into the blood and its availability in the body.

References

1. Legrand, D., Elass, E., Carpentier, M., & Mazurier, J. (2005). Lactoferrin: a modulator of immune and inflammatory responses. Cellular and molecular life sciences : CMLS, 62(22), 2549–2559. https://doi.org/10.1007/s00018-005-5370-2

2. Ward, P. P., Paz, E., & Conneely, O. M. (2005). Multifunctional roles of lactoferrin: a critical overview. Cellular and molecular life sciences : CMLS, 62(22), 2540–2548. https://doi.org/10.1007/s00018-005-5369-8

3. Iyer, S., & Lönnerdal, B. (1993). Lactoferrin, lactoferrin receptors and iron metabolism. European journal of clinical nutrition, 47(4), 232–241. "