Part:BBa_K5492401
Optimised Human Histamine-N-Methlytransferase - HNMT
Codon optimised coding DNA sequence of Human Histamne-N-Methyltransferase for an e.coli chassis, based on our part of BBa_K5492400
Usage and Biology
Histamine-N-Methlytransferase (HNMT) takes part in the inactivation of histamine. It transfers a methyl group to histamine, and the resulting N-methyl histamine isn’t able to bind to histamine receptors, thus reducing the biological effect of the compound. Limiting the level of histamine effect can be an appropriate approach in cases of inflammation, where you can anticipate the histamine level increase. On our skin this includes some chronic diseases such as psoriasis, but more often would be useful in handling the acute increase of histamine level, such as a wasp bite. The decrease in oral histamine administration may also help to prevent some acute GI inflammation and smoothing the symptoms of some chronic bowel diseases.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 100
- 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 100
- 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 100
- 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 100
- 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 100
- 1000COMPATIBLE WITH RFC[1000]
| None |