Part:BBa_K3392001
LL-37
Cathelicidin peptide is a kind of peptide family protein which can inhibit the protease Cathepsin-L and has antimicrobial effect. Cathelicidin peptide is a kind of peptide family protein which can inhibit the protease cathepsin-l and has anti microbial effect.LL-37 may play an antibacterial role in Hp induced gastritis.
LL-37, known as hCAP18 as well, is the C-terminal part of the unique human cathelicidin identified to date named human cationic antimicrobial protein (hCAP).
LL-37 exhibits a variety of immunomodulatory functions such as bactericidal action, chemotaxis, activation of chemokine secretion and antisepsis effect [1].
The synthetic LL-37 peptide has been shown to suppress the inflammatory response induced by LPS and other TLR ligands [2].
Characterization with literatures
“Koji Hase draws the conclusions: H. pylori up-regulates production of LL-37/hCAP18 by gastric epithelium, which suggest this cathelicidin contributes to determining the balance between host mucosal defense and H. pylori survival mechanisms that govern chronic infection with this gastric pathogen.” Here are the results.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal XhoI site found at 112
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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