Protein_Domain

Part:BBa_K3704000

Designed by: Kong Yangyang   Group: iGEM20_ECNUAS   (2020-10-17)
Revision as of 10:10, 17 October 2020 by Registry (Talk | contribs)

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GR

BBa_K3704000 is a protein domain of the glucocorticoid receptor (PubMed:27120390). Has a dual mode of action: a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation, and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner that recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BamHI site found at 705
    Illegal BamHI site found at 858
    Illegal BamHI site found at 972
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 1270
    Illegal AgeI site found at 558
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None