Part:BBa_K5477018
UDPD - UDP-glucose dehydrogenase
UDPD (UDP-glucose dehydrogenase) is an enzyme that plays a pivotal role in the biosynthesis of UDP-glucuronic acid, which is an essential precursor for the glucuronidation process carried out by UDP-glucuronosyltransferase (UGT) enzymes. Specifically, UDPD catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid, a reaction that supplies the glucuronic acid moiety used by UGT enzymes like UGT2B15 for the detoxification of various substances. Glucuronidation is a critical detoxification mechanism in the body’s phase II metabolism, where lipophilic (fat-soluble) compounds, such as drugs, environmental toxins, and endogenous substances like hormones, are conjugated with glucuronic acid to make them more water-soluble. This transformation facilitates their excretion from the body via urine or bile. UDP-glucuronic acid, produced by UDPD, is a central molecule in this process because it serves as the donor of glucuronic acid for UGT enzymes (1).
In our detoxification modules, UDPD is an essential enzyme that provides the necessary substrate for the glucuronidation reactions where UGT1A1 and UGT2B15 were used. The following composites and devices, where this part was used, is listed below:
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 542
- 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 542
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1122
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 542
- 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 542
- 1000COMPATIBLE WITH RFC[1000]
References
1. Rowland A, Miners JO, Mackenzie PI. The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification. Int J Biochem Cell Biol. 2013;45(6):1121-1132. doi:10.1016/j.biocel.2013.02.019
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