Part:BBa_K3852003
PHO3
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. Several papers have shown that bitter substances are recognized by the bitter receptor TAS2R, a family of G protein-coupled receptors expressed in taste tissue. In humans, more than 25 TAS2Rs have been identified; some of these are activated by bitter substances and function as bitter taste receptors. Because many bitter tastants activate hTAS2R, it has been thought that humans perceive bitterness via those receptors. Experiments show that a variety of bitter peptides can activate T2R4.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 610
- 1000COMPATIBLE WITH RFC[1000]
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