Coding

Part:BBa_K3392001

Designed by: Zhichen Guo   Group: iGEM20_UCAS-China   (2020-10-23)
Revision as of 01:23, 28 October 2020 by ZhangXE CAS (Talk | contribs)


LL-37

Cathelicidin peptide is a kind of peptide family protein which can inhibit the protease Cathepsin-L and has antimicrobial effect. Cathelicidin peptide is a kind of peptide family protein which can inhibit the protease cathepsin-l and has anti microbial effect.LL-37 may play an antibacterial role in Hp induced gastritis.

LL-37, known as hCAP18 as well, is the C-terminal part of the unique human cathelicidin identified to date named human cationic antimicrobial protein (hCAP).

LL-37 exhibits a variety of immunomodulatory functions such as bactericidal action, chemotaxis, activation of chemokine secretion and antisepsis effect [1].

The synthetic LL-37 peptide has been shown to suppress the inflammatory response induced by LPS and other TLR ligands [2].

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 112
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None