Part:BBa_K1613005
A composite part that can detect some toxins.
cyp1a2 can oxidize the substances that it can metabolism.
Cytochrome P450 1A2 is a member of the cytochrome P450 mixed-function oxidase system. And it is involved in the metabolism of xenobiotics in the body. Function The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include aflatoxin B1, and acetaminophen.
Substrates
many antidepressants some atypical antipsychotics
amitriptyline clozapine
clomipramine olanzapine ropivacaine tizanidine
theophylline zolmitriptan
melatonin tamoxifen
erlotinib cyclobenzaprine
estradiol fluvoxaminemexiletine
naproxen ondansetron
phenacetin paracetamol
propranolol riluzole
tacrine
verapamil warfarin[
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 7
Illegal NheI site found at 30 - 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1464
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 384
Illegal NgoMIV site found at 471
Illegal AgeI site found at 454 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 1184
None |