Part:BBa_K4839008

IRF4 Binding protein

Our modeling work also contribute to our part collection. In order to directly target to the IRF4 protein (Figure 1.), we synthesis an IRF4 binding protein through modeling. The detailed process of our modeling work can be found on the model page.

Figure1. The function of anti-IRF4 BioPROTAC

With the help of computer modeling including molecular dynamics, we succeedly synthesis the Anti-IRF4 protein, which is called IRF4 binding protein here. The IRF4 binding protein can specifically binds to the IRF4 protein, and thus the BioPROTAC will trigger the degradation of the IRF4 and furher lead to the changing of the phenotype of the macrophage.

Sequence and Features

Assembly Compatibility:

• 10
  INCOMPATIBLE WITH RFC[10]

  Illegal PstI site found at 271
  
• 12
  INCOMPATIBLE WITH RFC[12]

  Illegal PstI site found at 271
  
• 21
  COMPATIBLE WITH RFC[21]
• 23
  INCOMPATIBLE WITH RFC[23]

  Illegal PstI site found at 271
  
• 25
  INCOMPATIBLE WITH RFC[25]

  Illegal PstI site found at 271
  Illegal AgeI site found at 548
  
• 1000
  COMPATIBLE WITH RFC[1000]