Coding

Part:BBa_K4020002

Designed by: Karina Kurbanova   Group: iGEM21_Estonia_TUIT   (2021-10-18)
Revision as of 04:39, 21 October 2021 by Karina2 (Talk | contribs) (→‎References)

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Usage and Biology

SIC1∆N is a gene encoding a protein that inhibits cyclin-dependent kinase complexes and G1 to S phase progression in cell cycle (Hegde, 2010a), prevents premature S phase entry, and warrants genome integrity (Hegde, 2010b). It is genomic DNA. The deletion of the first 90 nucleotides encoding the N-terminus, or the regulatory domain of the corresponding protein, results in a non-degradable Sic1 variant.

References

  • Hegde, A.N. (2010a). Ubiquitin-Dependent Protein Degradation. Comprehensive Natural Products II: Chemistry and Biology 5, 699–752.
  • Hegde, A.N. (2010b). 5.21 - Ubiquitin-Dependent Protein Degradation. In Comprehensive Natural Products II, H.-W. (Ben) Liu, and L. Mander, eds. (Oxford: Elsevier), pp. 699–752.
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