Difference between revisions of "Part:BBa K380010"

Revision as of 17:43, 27 October 2010

Immunoglobulin G protease (IdeS)

Immunoglobulin G protease (IdeS) is a proteolytic enzyme produced by Streptococcus pyogenes. The protein is designated to IdeS for Immunoglobulin G-degrading enzyme of S. pyogenes. This streptococcal cysteine proteinase, IdeS, is an immunoglobulin-degrading enzyme. It has a high specificity to cleave human IgG antibodies at the hinge region.

Reference:

IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. von Pawel-Rammingen U et al. EMBO J. 2002 Apr 2;21(7):1607-15.
IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes. von Pawel-Rammingen U et al. Curr Opin Microbiol. 2003 Feb;6(1):50-5.

Immunoglobulin G protease (IdeS): Protein name: IgG-degrading protease.

Molecular function: Protease

Protein existence: Evidence at protein level. http://www.uniprot.org/uniprot/Q7DAM2. The identification, purification and characterization of IgG protease (IdeS) was first done by IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. von Pawel-Rammingen U et al. EMBO J. 2002 Apr 2;21(7):1607-15.

Our iGEM group recived this gene from http://www.umu.se/sok/english/staff-directory/view-person?uid=ulvo0001.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 268

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 __NOTOC__
 <partinfo>BBa_K380010 short</partinfo>
-long description
+Immunoglobulin G protease (IdeS) is a proteolytic enzyme produced by Streptococcus pyogenes. The protein is designated to IdeS for Immunoglobulin G-degrading enzyme of S. pyogenes. This streptococcal cysteine proteinase, IdeS, is an immunoglobulin-degrading enzyme.  It has a high specificity to cleave human IgG antibodies at the hinge region.
+Reference:
+* IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. von Pawel-Rammingen U et al. EMBO J. 2002 Apr 2;21(7):1607-15.
+* IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes. von Pawel-Rammingen U et al. Curr Opin Microbiol. 2003 Feb;6(1):50-5.
+Immunoglobulin G protease (IdeS):
+Protein name: IgG-degrading protease.
+Molecular function: Protease
+Protein existence: Evidence at protein level. http://www.uniprot.org/uniprot/Q7DAM2. The identification, purification and characterization of IgG protease (IdeS) was first done by IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. von Pawel-Rammingen U et al. EMBO J. 2002 Apr 2;21(7):1607-15.
+Our iGEM group recived this gene from http://www.umu.se/sok/english/staff-directory/view-person?uid=ulvo0001.
 <!-- Add more about the biology of this part here