Difference between revisions of "Part:BBa K320015"
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<partinfo>BBa_K320015 short</partinfo> | <partinfo>BBa_K320015 short</partinfo> | ||
| − | + | This BioBrick contains the protein P25. | |
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| + | The ookinete (Plasmodium stage in mosquito's gut) has been intensively studied by scientists, looking for an ideal transmission-blocking vaccine target. IGEM EPFL team's was interested in the ookinete surface membrane proteins Pfs25 and Pfs28 (link to other biobrick). It has been shown that the binding of specific antibodies to these surface proteins was fatal to more than 99% of the ookinetes. Indeed, P25 and P28 seem to be essential for the ookinete to be able to cross the midgut epithelium and thereafter transform into an oocyst. | ||
<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
Latest revision as of 13:00, 27 October 2010
P25
This BioBrick contains the protein P25.
The ookinete (Plasmodium stage in mosquito's gut) has been intensively studied by scientists, looking for an ideal transmission-blocking vaccine target. IGEM EPFL team's was interested in the ookinete surface membrane proteins Pfs25 and Pfs28 (link to other biobrick). It has been shown that the binding of specific antibodies to these surface proteins was fatal to more than 99% of the ookinetes. Indeed, P25 and P28 seem to be essential for the ookinete to be able to cross the midgut epithelium and thereafter transform into an oocyst.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]