Difference between revisions of "Part:BBa K316015"
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__NOTOC__ | __NOTOC__ | ||
<partinfo>BBa_K316015 short</partinfo> | <partinfo>BBa_K316015 short</partinfo> | ||
− | ComD is the histidine kinase of a two-component signal transduction signaling pathway in a Streptococcus pneumoniae quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1) which is coded for by the | + | |
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+ | ComD is the histidine kinase of a two-component signal transduction signaling pathway in a ''Streptococcus pneumoniae'' quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1)[http://www.ncbi.nlm.nih.gov/pubmed/17328748] which is coded for by the comC gene. Upon detection of CSP-1, ComD will autophosphoylate and then phosphorylate and activate the response regulator, ComE. | ||
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+ | ComD is sensitive to ComC concentrations as low as 2-10 ng/ul.[http://www.ncbi.nlm.nih.gov/pubmed/7479953] | ||
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+ | For more information on ComCDE system, please check our wiki [http://2010.igem.org/Team:Imperial_College_London/Modules/Signaling] | ||
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<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
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− | <span class='h3bb'>Sequence and Features</span> | + | <span class='h3bb'><big>'''Sequence and Features'''</big></span> |
<partinfo>BBa_K316015 SequenceAndFeatures</partinfo> | <partinfo>BBa_K316015 SequenceAndFeatures</partinfo> | ||
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<partinfo>BBa_K316015 parameters</partinfo> | <partinfo>BBa_K316015 parameters</partinfo> | ||
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+ | ===References=== | ||
+ | <biblio> | ||
+ | #1 Halfmann et.al. FEMS Microbiol Lett. 2007 Mar;268(2):217-24 | ||
+ | #2 Håvarstein et.al. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11140-4 | ||
+ | </biblio> |
Revision as of 17:36, 26 October 2010
ComD receptor for CSP-1 (S. pneumoniae), phosphorylates ComE
ComD is the histidine kinase of a two-component signal transduction signaling pathway in a Streptococcus pneumoniae quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1)[http://www.ncbi.nlm.nih.gov/pubmed/17328748] which is coded for by the comC gene. Upon detection of CSP-1, ComD will autophosphoylate and then phosphorylate and activate the response regulator, ComE.
ComD is sensitive to ComC concentrations as low as 2-10 ng/ul.[http://www.ncbi.nlm.nih.gov/pubmed/7479953]
For more information on ComCDE system, please check our wiki [http://2010.igem.org/Team:Imperial_College_London/Modules/Signaling]
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1363
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
References
<biblio>
- 1 Halfmann et.al. FEMS Microbiol Lett. 2007 Mar;268(2):217-24
- 2 Håvarstein et.al. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11140-4
</biblio>