Difference between revisions of "Part:BBa K404204"
(→Usage and Biology) |
(→Usage and Biology) |
||
| Line 8: | Line 8: | ||
===Usage and Biology=== | ===Usage and Biology=== | ||
| − | The Z34C antibody binding motif is a 34 amino acids long fragment from the a minimized fragment of the Z Domain of [http://www.ncbi.nlm.nih.gov/protein/153106 Staphylococcal Protein A]. It specifically binds to the Fc-Domain of antibodies. If inserted into AAV capsids, it can bind antibodies against a specific antigen, allowing differential targeting without further genetic engineering. | + | The Z34C antibody binding motif is a 34 amino acids long fragment from the a minimized fragment of the Z Domain of [http://www.ncbi.nlm.nih.gov/protein/153106 Staphylococcal Protein A]. It specifically binds to the Fc-Domain of antibodies. If inserted into AAV capsids, it can bind antibodies against a specific antigen, allowing differential targeting without the need for further genetic engineering. |
[[Image:Freiburg10_ViralBrick_motif_Z34C.png|thumb|center|480px]] | [[Image:Freiburg10_ViralBrick_motif_Z34C.png|thumb|center|480px]] | ||
Revision as of 13:12, 26 October 2010
ViralBrick-453-Z34C
The Z34C antibody binding motif, ready for insertion into the 453 loop
Usage and Biology
The Z34C antibody binding motif is a 34 amino acids long fragment from the a minimized fragment of the Z Domain of [http://www.ncbi.nlm.nih.gov/protein/153106 Staphylococcal Protein A]. It specifically binds to the Fc-Domain of antibodies. If inserted into AAV capsids, it can bind antibodies against a specific antigen, allowing differential targeting without the need for further genetic engineering.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]