Difference between revisions of "Part:BBa K364307:Experience"

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how you used this part and how it worked out.
 
how you used this part and how it worked out.
  
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===Ligand===
 
  
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Estrogens (ER)
 
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Estrogens (AmE), oestrogens (BE), or œstrogens, are a group of steroid compounds,
 
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named  for  their  importance  in  the  estrous  cycle,  and  functioning  as  the  primary
 
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female  sex  hormone.  Their  name  comes  from  estrus/oistros  (period  of  fertility  for
 
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female mammals) + gen/gonos = to generate.
 
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Estrogens
 
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of  these  steroids  in  both  vertebrate  and  insects  suggests  that  estrogenic  sex
 
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hormones have an ancient history.
 
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Estrogens  are  used  as  part  of  some  oral  contraceptives,  in  estrogen  replacement
 
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therapy  for  postmenopausal  women,  and  in  hormone  replacement  therapy  for  trans
 
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women.
 
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Like inside  the  cell,  they  bind  to  and  activate  estrogen  receptors  which  in  turn  modulate
 
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the expression of many genes. Additionally, estrogens have been shown to activate a G protein-coupled receptor, GPR30.
 
  
 
===Physiological effects of ER===
 
===Physiological effects of ER===

Latest revision as of 01:53, 26 October 2010

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Physiological effects of ER

In the absence of hormone, estrogen receptors are largely located in the cytosol. Hormone binding to the receptor triggers a number of events starting with migration of the receptor from the cytosol into the nucleus, dimerization of the receptor, and subsequent binding of the receptor dimer to specific sequences of DNA. Some of the effects in humans: Createing proliferative endometrium,breast cell stimulation, increased body fat and weight gain, salt and fluid retention, increased risk of blood clots.

Potential applications of ER DBD

ER-DBD can be fused with various LBDs in order to get heterogenous composite Nuclear Receptors. With addition of the LBD's ligand the receptor can bind to Estrogen Receptor Response element and activate downstream gene expression.

Applications of BBa_K364307

User Reviews

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