Difference between revisions of "Part:BBa K364329:Experience"

Revision as of 23:31, 25 October 2010

This experience page is provided so that any user may enter their experience using this part.
Please enter how you used this part and how it worked out.

Physiological effects of ER

In the absence of hormone, estrogen receptors are largely located in the cytosol. Hormone binding to the receptor triggers a number of events starting with migration of the receptor from the cytosol into the nucleus, dimerization of the receptor, and subsequent binding of the receptor dimer to specific sequences of DNA. Some of the effects in humans: Createing proliferative endometrium,breast cell stimulation, increased body fat and weight gain, salt and fluid retention, increased risk of blood clots.

Potential applications of ER DBD-VDR hinge-ER LBD

With the usage of this part, we can examine the effect of the hinge insertion into the original Estrogen receptor.

Applications of BBa_K364329

User Reviews

UNIQ78c421a5f70159b9-partinfo-00000000-QINU UNIQ78c421a5f70159b9-partinfo-00000001-QINU

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 __NOTOC__
 This experience page is provided so that any user may enter their experience using this part.<BR>Please enter
 how you used this part and how it worked out.
+===Physiological effects of ER===
+In the absence of hormone, estrogen receptors are largely located in the cytosol. Hormone binding to the receptor triggers a number of events starting with migration of the receptor from the cytosol into the nucleus, dimerization of the receptor, and subsequent binding of the receptor dimer to specific sequences of DNA. Some of the effects in humans: Createing proliferative endometrium,breast cell stimulation, increased body fat and weight gain, salt and fluid retention, increased risk of blood clots.
+===Potential applications of ER DBD-VDR hinge-ER LBD===
+With the usage of this part, we can examine the effect of the hinge insertion into the original Estrogen receptor.
 ===Applications of BBa_K364329===