Difference between revisions of "Part:BBa K364314:Experience"
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NHR8 is required for gut function and may respond to the food signal. | NHR8 is required for gut function and may respond to the food signal. | ||
| − | The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine. | + | The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors. NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3. |
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| − | This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors. | + | |
| − | NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3. | + | |
===Possible applications of NHR8 LBD=== | ===Possible applications of NHR8 LBD=== | ||
Revision as of 18:16, 25 October 2010
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Physiological functions of NHR8
NHR8 is required for gut function and may respond to the food signal.
The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors. NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3.
Possible applications of NHR8 LBD
This LBD can be fused with different DBDs forming a composite hormone receptor for ligand regulated expression of specific genes and can also be a sensor for various lipid natured molecules.
Applications of BBa_K364314
User Reviews
UNIQ191673a9dabb5710-partinfo-00000000-QINU UNIQ191673a9dabb5710-partinfo-00000001-QINU