Difference between revisions of "Part:BBa K364314:Experience"

Revision as of 18:15, 25 October 2010

This experience page is provided so that any user may enter their experience using this part.
Please enter how you used this part and how it worked out.

Physiological functions of NHR8

NHR8 is required for gut function and may respond to the food signal.

The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.

This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors. NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3.

Possible applications of NHR8 LBD

This LBD can be fused with different DBDs forming a composite hormone receptor for ligand regulated expression of specific genes and can also be a sensor for various lipid natured molecules.

Applications of BBa_K364314

User Reviews

UNIQc8d3c6884e89ebaf-partinfo-00000000-QINU UNIQc8d3c6884e89ebaf-partinfo-00000001-QINU

@@ Line 1: / Line 1: @@
 __NOTOC__
 This experience page is provided so that any user may enter their experience using this part.<BR>Please enter
 how you used this part and how it worked out.
+===Physiological functions of NHR8===
+NHR8 is required for gut function and may respond to the food signal.
+The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.
+This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors.
+NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3.
+===Possible applications of NHR8 LBD===
+This LBD can be fused with different DBDs forming a composite hormone receptor for ligand regulated expression of specific genes and can also be a sensor for various lipid natured molecules.
 ===Applications of BBa_K364314===