Difference between revisions of "Part:BBa K364310"

Revision as of 16:57, 25 October 2010

EcR LBD

The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, which ultimately causes physiological changes that result in ecdysis (moulting).

Picture of EcR-LBD USP heterodimer

Picture of gel electrophoresis: EcR LBD in pSB1C3 results a 768 bp long insert

Sequence and Features