Difference between revisions of "Part:BBa K364309:Experience"
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| − | ER LBD can be fused with different DBDs in order to get composite nuclear receptors | + | ER LBD can be fused with different DBDs in order to get heterogenous composite nuclear receptors activating gene expression depending on the binding site of the fused DBD. |
===Applications of BBa_K364309=== | ===Applications of BBa_K364309=== | ||
Revision as of 22:58, 24 October 2010
This experience page is provided so that any user may enter their experience using this part.
Please enter
how you used this part and how it worked out.
Physiological effects of ER
In the absence of hormone, estrogen receptors are largely located in the cytosol. Hormone binding to the receptor triggers a number of events starting with migration of the receptor from the cytosol into the nucleus, dimerization of the receptor, and subsequent binding of the receptor dimer to specific sequences of DNA. Some of the effects in humans: Createing proliferative endometrium,breast cell stimulation, increased body fat and weight gain, salt and fluid retention, increased risk of blood clots.
Potential applications
ER LBD can be fused with different DBDs in order to get heterogenous composite nuclear receptors activating gene expression depending on the binding site of the fused DBD.
Applications of BBa_K364309
User Reviews
UNIQ061cb4bec921e726-partinfo-00000000-QINU UNIQ061cb4bec921e726-partinfo-00000001-QINU