Difference between revisions of "Part:BBa K5198003"

 
Line 3: Line 3:
 
<partinfo>BBa_K5198003 short</partinfo>
 
<partinfo>BBa_K5198003 short</partinfo>
  
−
In progress
+
Single-chain variable fragment derived from the SJ25C1 antibody, which has strong affinity for the extracellular domain of CD19 [1]. By recognizing and binding to CD19, this scFv can potentially be used in therapeutic applications, where T-cells are engineered to express the scFv on their surface, enabling them to target and destroy CD19-positive B-cells.
  
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here
−
===Usage and Biology===
+
===References===
 +
[1] C. He et al., “CD19 CAR antigen engagement mechanisms and affinity tuning,” Sci Immunol, vol. 8, no. 81, p. eadf1426, Mar. 2023, doi: 10.1126/sciimmunol.adf1426.
  
 
<!-- -->
 
<!-- -->

Revision as of 09:02, 2 October 2024


antiCD19 scFv SJ25C1 WT

Single-chain variable fragment derived from the SJ25C1 antibody, which has strong affinity for the extracellular domain of CD19 [1]. By recognizing and binding to CD19, this scFv can potentially be used in therapeutic applications, where T-cells are engineered to express the scFv on their surface, enabling them to target and destroy CD19-positive B-cells.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]