Difference between revisions of "Part:BBa K5499007"
 
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<partinfo>BBa_K5499007 short</partinfo>
 
<partinfo>BBa_K5499007 short</partinfo>
  
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Lysosome-associated membrane protein 2, isoform A (LAMP2A), serves as a receptor and channel for transporting cytosolic proteins.
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Lysosome-associated membrane protein type 2A (LAMP2A) is a crucial protein involved in exosome formation.
  
 
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===Profile===
 
===Profile===
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Name: LAMP2A Mature Peptide
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Name: LAMP2A (Lysosomal-associated membrane protein 2A) mature peptide
  
 
Base Pairs:1146 bp
 
Base Pairs:1146 bp
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Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.
 
Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.
  
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Properties: The LAMP2A mature peptide plays a crucial role in lysosomal function, particularly in chaperone-mediated autophagy (CMA). It facilitates the recognition and translocation of specific cytosolic proteins into the lysosome for degradation. This peptide is characterized by its ability to interact with various proteins and is integral to maintaining cellular homeostasis and regulating lysosomal pathways.
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Properties: LAMP2A's structure facilitates its ability to promote the selective recognition and transport of cytoplasmic proteins containing specific targeting motifs, such as the KFERQ sequence.
  
 
===Usage and Biology===
 
===Usage and Biology===
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The LAMP2A mature peptide is utilized in various biotechnological and therapeutic applications, particularly in the field of gene therapy and lysosomal enzyme replacement therapies. Its ability to mediate the delivery of proteins to lysosomes makes it valuable for treating lysosomal storage disorders and enhancing the clearance of aggregated proteins in neurodegenerative diseases.
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LAMP2A is involved in recognizing proteins destined for degradation or exosomal secretion by binding to the chaperone-protein complex at the lysosomal membrane. Upon binding, it facilitates the translocation of these proteins into the lysosome for degradation or packaging into multivesicular bodies (MVBs) for exosomal secretion. The interaction between LAMP2A and the KFERQ-like motifs allows for the selective uptake of proteins, ensuring that unwanted or misfolded proteins are efficiently handled by the cell.This positions LAMP2A as a key player in the regulation of protein sorting within cells and the modulation of extracellular signaling through exosomes.
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The LAMP2A mature peptide is an essential component of the lysosomal membrane and plays a pivotal role in chaperone-mediated autophagy (CMA). By facilitating the selective uptake of cytosolic proteins into the lysosome, it helps maintain cellular homeostasis. The LAMP2A-mediated pathway is critical for the degradation of damaged or misfolded proteins, thereby preventing cellular toxicity. Understanding the biology of LAMP2A is important for developing strategies to manipulate lysosomal function in various diseases.
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Latest revision as of 23:23, 1 October 2024


LAMP2A mature peptide

Lysosome-associated membrane protein type 2A (LAMP2A) is a crucial protein involved in exosome formation.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Profile

Name: LAMP2A (Lysosomal-associated membrane protein 2A) mature peptide

Base Pairs:1146 bp

Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.

Properties: LAMP2A's structure facilitates its ability to promote the selective recognition and transport of cytoplasmic proteins containing specific targeting motifs, such as the KFERQ sequence.

Usage and Biology

LAMP2A is involved in recognizing proteins destined for degradation or exosomal secretion by binding to the chaperone-protein complex at the lysosomal membrane. Upon binding, it facilitates the translocation of these proteins into the lysosome for degradation or packaging into multivesicular bodies (MVBs) for exosomal secretion. The interaction between LAMP2A and the KFERQ-like motifs allows for the selective uptake of proteins, ensuring that unwanted or misfolded proteins are efficiently handled by the cell.This positions LAMP2A as a key player in the regulation of protein sorting within cells and the modulation of extracellular signaling through exosomes.