Difference between revisions of "Part:BBa K5271006"

 
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<partinfo>BBa_K5271006 short</partinfo>
 
<partinfo>BBa_K5271006 short</partinfo>
  
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A linker
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A 3x GSSG linker connecting HER2 and EGFR nanobody domains.
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===Usage and Biology===
 
===Usage and Biology===
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The GS linker is a 12 amino acid long sequence containing 3x GSSG tandems connecting HER2 and EGFR nanobody. This basic part ensure a spatial separation between the two nanobody domains to achieve antigen binding or improve protein folding
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===Reference===
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*Chen, X.; Zaro, J. L.; Shen, W.-C. Fusion Protein Linkers: Property, Design and Functionality. Advanced Drug Delivery Reviews 2013, 65 (10), 1357–1369. https://doi.org/10.1016/j.addr.2012.09.039.
  
 
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Revision as of 09:34, 29 September 2024


Linker

A 3x GSSG linker connecting HER2 and EGFR nanobody domains.



Usage and Biology

The GS linker is a 12 amino acid long sequence containing 3x GSSG tandems connecting HER2 and EGFR nanobody. This basic part ensure a spatial separation between the two nanobody domains to achieve antigen binding or improve protein folding


Reference

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]