Difference between revisions of "Part:BBa K5115070"
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__TOC__ | __TOC__ | ||
===Introduction=== | ===Introduction=== | ||
| + | YejM is an anti-adaptor protein that can regulate the synthesis of the LPS. In ''E.coli'', LPS levels are | ||
| + | under feedback control, achieved by FtsH-mediated degradation of LpxC. FtsH is a membrane- | ||
| + | bound AAA+ protease, and its protease activity toward LpxC is regulated by | ||
| + | essential membrane proteins LapB and YejM. YejM can compete with FtsH for LapB to inhibit LpxC | ||
| + | degradation, thus guaranteed the expression level of LPS.<ref>Shu, S., & Mi, W. (2022). Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli. Nature Communications, 13(1), 4576.</ref> | ||
===Usage and Biology=== | ===Usage and Biology=== | ||
| + | |||
===Characterization=== | ===Characterization=== | ||
Revision as of 12:39, 28 September 2024
YejM
Introduction
YejM is an anti-adaptor protein that can regulate the synthesis of the LPS. In E.coli, LPS levels are under feedback control, achieved by FtsH-mediated degradation of LpxC. FtsH is a membrane- bound AAA+ protease, and its protease activity toward LpxC is regulated by essential membrane proteins LapB and YejM. YejM can compete with FtsH for LapB to inhibit LpxC degradation, thus guaranteed the expression level of LPS.[1]
Usage and Biology
Characterization
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 1440
- 1000COMPATIBLE WITH RFC[1000]
References
- ↑ Shu, S., & Mi, W. (2022). Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli. Nature Communications, 13(1), 4576.