Difference between revisions of "Part:BBa K257018"
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The cell envelope of gram-negative bacteria consists of two membranes, the cytoplasmic or inner membrane and the outer membrane. Transport of proteins across the inner membrane in most cases follows the general secretory pathway (GSP). Therefore, in gram-negative bacteria, proteins end up in the periplasm. To translocate proteins to the outer surface or into the supernatant, gram-negative bacteria have developed several distinct mechanisms. In contrast to the secretory systems that require a variety of specialized accessory proteins that, often in combination with the GSP, are responsible for the export of one or several passenger proteins into the supernatant, the autotransporter protein family members carry the export signal and machinery within a single polypeptide chain. The adhesin-involved-in-diffuse-adherence (AIDA) autotransporter has been identified as a virulence factor of the enteropathogenic Escherichia coli strain 2787 and predicted to be a member of the autotransporter protein family. | The cell envelope of gram-negative bacteria consists of two membranes, the cytoplasmic or inner membrane and the outer membrane. Transport of proteins across the inner membrane in most cases follows the general secretory pathway (GSP). Therefore, in gram-negative bacteria, proteins end up in the periplasm. To translocate proteins to the outer surface or into the supernatant, gram-negative bacteria have developed several distinct mechanisms. In contrast to the secretory systems that require a variety of specialized accessory proteins that, often in combination with the GSP, are responsible for the export of one or several passenger proteins into the supernatant, the autotransporter protein family members carry the export signal and machinery within a single polypeptide chain. The adhesin-involved-in-diffuse-adherence (AIDA) autotransporter has been identified as a virulence factor of the enteropathogenic Escherichia coli strain 2787 and predicted to be a member of the autotransporter protein family. | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Latest revision as of 16:43, 21 October 2009
AIDA-I autotransporter, linker + translocator domains
The cell envelope of gram-negative bacteria consists of two membranes, the cytoplasmic or inner membrane and the outer membrane. Transport of proteins across the inner membrane in most cases follows the general secretory pathway (GSP). Therefore, in gram-negative bacteria, proteins end up in the periplasm. To translocate proteins to the outer surface or into the supernatant, gram-negative bacteria have developed several distinct mechanisms. In contrast to the secretory systems that require a variety of specialized accessory proteins that, often in combination with the GSP, are responsible for the export of one or several passenger proteins into the supernatant, the autotransporter protein family members carry the export signal and machinery within a single polypeptide chain. The adhesin-involved-in-diffuse-adherence (AIDA) autotransporter has been identified as a virulence factor of the enteropathogenic Escherichia coli strain 2787 and predicted to be a member of the autotransporter protein family.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 1118
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]