Difference between revisions of "Part:BBa K5107001"

Revision as of 15:45, 22 September 2024

ERE minimal

Estrogen Response Element (ERE) is the consensus sequence for the binding site of the estrogen receptor.

Sequence and Features

Assembly Compatibility:

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 <partinfo>BBa_K5107001 short</partinfo>
-HRE5 is the 5 times repeats of th HRE minimal to increase the interaction surface of the hormone receptor with the DNA.
+Estrogen Response Element (ERE) is the consensus sequence for the binding site of the estrogen receptor.
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 ===Usage and Biology===
+These inverted repeats are responsible for the interaction of the DNA Binding Domain (DBD) of the receptor with the DNA. In the human cells, these nuclear receptors work mainly as transctription activators when the hormone is present in the cytoplasm. There, protein-hormone interactions trigger the translocation of the receptor to the nucleus where the transcription takes place. Because of the absence of the cofactors in the cell free system, these sites are used as operator sites, meaning that the nuclear receptor-hormone complex can bind to these and block the transcription of the upstream promoter.
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